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Glookbib search for: zz0422

%A S. Luca
%A T. Mihaescu
%T History of BCG vaccine
%J Maedica (Bucur)
%V 8
%N 1
%P 53-58
%M MAR
%D 2013
%K jrnl, MolBio, tuberculosis, TB, c2013, c201x, c20xx, zz0422, human health,
   disease, BCG, vaccine, vaccination, tubercle bacillus,
   Bacille Calmette Guerin
%X "... (TB) is still responsible for 2 million deaths every year despite being
   a treatable airborne infectious disease. 'Consumption' and 'Phthisis' were
   terms historically used to describe TB, which was responsible for one in four
   deaths in the 19th C.. ... the emergence of multi-drug resistant TB & the
   current TB-HIV epidemic ... Bacille Calmette-Guerin (BCG) is the only vaccine
   available today and has been used for more than 90 years with astonishing
   safety records. However, its efficacy remains controversial. ..."
   -- [www]['22].
   [Also search for: BCG vaccine].

%A S. Nurk
%A et al
%T The complete sequence of a human genome
%J Science
%V 376
%N 6588
%P 44-53
%M MAR
%D 2022
%K jrnl, MolBio, c2022, c202x, c20xx, zz0422, human genome, nGenome,
   chromosomes, telomere, centromere, acrocentric, reference,
   T2T-CHM13, C2TCHM13
%X "... the Telomere-to-Telomere (T2T) Consortium presents a complete 3.055
   billion-base pair seq. of a h.genome, T2T-CHM13, that includes gapless
   assemblies for all chr. except Y, corrects errors in the prior references,
   & introduces nearly 200 million bps of seq. containing 1956 gene predictions,
   99 of which are pred. to be protein coding. The completed regions inc. all
   centromeric satellite arrays, recent segmental duplications, & the short
   arms of all five acrocentric chromosomes ..."
   -- [doi:10.1126/science.abj6987]['22].
   (in special issue on completeing the human genome.)

%A Longxing Cao
%A et al ...
%A D. Baker
%T Design of protein binding proteins from target structure alone
%J Nature
%V ?
%M MAR
%D 2022
%K jrnl, MolBio, c2022, c202x, c20xx, zz0422, protein, computer design, silico,
   antibody
%X "... The design of proteins that bind to a specific site on the surface of a
   target p. using no info. other than the 3S structure of the target remains an
   outstanding challenge. We describe a general soln to this problem which
   starts with a broad exploration of the very large space of possible binding
   modes to a selected region of a p.surface, & then intensifies the search in
   the vicinity of the most promising binding modes. We demonstrate its very
   broad applicability by de novo design of binding proteins to 12 diverse
   p.targets ..."
   -- [doi:10.1038/s41586-022-04654-9]['22] (online 24/3/2022).
   [Also search for: MolBio protein design].

%A K. Roper
%A et al ...
%A R. D. King
%T Testing the reproducibility and robustness of the cancer biology literature
   by robot
%J J. Royal Soc., Interface
%M APR
%D 2022
%K jrnl, c2022, c202x, c20xx, zz0422, MolBio, robot, Eve, robotic, automated,
   science, scientific research, breast cancer, MCF7, GWAS, reproducibility
%X "... From 12,260 papers, we automatically extracted statements predicted to
   describe experimental results regarding a change of gene expression in
   response to drug treatment in breast cancer, from these we selected 74
   statements of high biomedical interest. To test the reproducibility of these
   statements, two different teams used the laboratory automation system Eve &
   two breast cancer cell lines (MCF7 & MDA-MB-231). Stat. sig. evidence for
   repeatability was found for 43 statements, & sig. evidence for
   reproducibility/robustness in 22 statements. In two cases, the automation
   made serendipitous discoveries. The reproduced/robust knowledge provides
   sig. insight into cancer. We conclude that semi-automated reproducibility
   testing is currently achievable ..."
   -- [doi:10.1098/rsif.2021.0821]['22].

%A E. Callaway
%T What's next for AlphaFold and the AI protein-folding revolution
%J Nature
%V 604
%P 234-238
%M APR
%D 2022
%K news, views, c2022, c202x, c20xx, zz0422, MolBio, protein, structure,
   folding, prediction, AlphaFold, applications
%X "... AlphaFold caused a sensation in December 2020, when it dominated a
   contest called the Critical Assessment of Protein Structure Prediction, or
   CASP. ..."
   -- [doi:10.1038/d41586-022-00997-5]['22].
   (Also see Pfolding@[wikip['22].)
   [Also search for: AlphaFold].

%A A. Cagan
%A et al
%T Somatic mutation rates scale with lifespan across mammals
%J Nature
%V ?
%M APR
%D 2022
%K jrnl, MolBio, c2022, c202x, c20xx, zz0422, DNA, genome, somatic mutation,
   mutations, rate, lifespan, age, ageing, animal, mammal, lifespan
%X "... we performed whole-genome sequencing of 208 intestinal crypts from 56
   individuals to study the landscape of somatic mutation across 16 mammalian
   species. ... Notably, the somatic mutn rate per year varied greatly across
   species & exhibited a strong inverse relationship with species lifespan, with
   no other life-history trait studied showing a comparable assoc.. Despite
   widely different life histories among the species we examined - inc.
   variation of ~ 30-fold in lifespan & ~ 40,000-fold in body mass - the
   somatic mutn burden at the end of lifespan varied only by a factor of ~3.
   These data unveil common mutational processes across mammals, & suggest that
   somatic mutn rates are evolutionarily constrained & may be a contributing
   factor in ageing."
   -- [doi:10.1038/s41586-022-04618-z]['22].
   [Also search for: MolBio ageing].

%A M. A. Field
%A et al
%T The Australian dingo is an early offshoot of modern breed dogs
%J ScienceAdvances
%V 8
%N 16
%M APR
%D 2022
%K jrnl, MolBio, c2022, c202x, c20xx, zz0422, dog, dingo, canine, wolf, genome,
   evolution, breeding
%X "... We identified large chromosomal differences relative to the current dog
   reference (CanFam3.1) and confirmed no expanded pancreatic amylase gene as
   found in breed dogs. Phylogenetic analyses using variant pairwise matrices
   show that the dingo is distinct from five breed dogs with 100% bootstrap
   support when using Greenland wolf as the outgroup. Functionally, we observe
   differences in methylation patterns between the dingo and German shepherd dog
   genomes and differences in serum biochemistry and microbiome makeup. Our
   results suggest that distinct demographic and environmental conditions have
   shaped the dingo genome. In contrast, artificial human selection has likely
   shaped the genomes of domestic breed dogs after divergence from the dingo."
   -- [doi:10.1126/sciadv.abm5944]['22].
   (Also see [abc][23/4/2022].)

%A L. Smolin
%T Einstein's Unfinished Revolution: The Search for What Lies Beyond the Quantum
%I PenguinPress
%D 2019
%K book, c2019, c201x, c20xx, zz0422, physics, philosophy, cosmology,
   consciousness
%X 1st ed 2019; hb us$57; uk us isbn:1594206198; uk us isbn13:978-1594206191.
   "... theoretical physicist Lee Smolin provocatively argues that the problems
   which have bedeviled q.physics since its inception are unsolved & unsolvable
   for the simple reason that the theory is incomplete. ..."

%A W. Van Tilburg
%A E. Igou
%A M. Panjwani
%T Boring people: Stereotype characteristics, interpersonal attributions, and
   social reactions
%J Personality and Social Psychology Bull.
%M MAR
%D 2022
%K jrnl, c2022, c202x, c20xx, zz0422, human, behaviour, psychology, boring,
   dull, person, job, jobs, occupation
%X "... the underlying psychological processes & consequences of perceiving a
   person as 'boring' have been largely unexplored. We examined the stereot.
   features of boring others by having people generate (Study 1) & then rate
   (Study 2) these. We focused on occupations (e.g., data analytics, taxation,
   accounting), hobbies (e.g., sleeping, religion, watching TV), & personal
   characteristics (e.g., lacking humor & opinions, being negative) that people
   ascribed to stereotypically boring others. Experiments then showed that those
   who were ascribed boring characteristics were seen as lacking interpersonal
   warmth & competence (Study 3), were socially avoided (Study 4), & enduring
   their company required compensation (Study 5). These results suggest that
   being stereotyped as a bore may come with substantially -ve interpersonal
   consequences."
   -- [doi:10.1177/01461672221079104]['22],
      [essex.ac.uk]['22].
   (ignobel candidate?  Not interesting enough?)

%A D. Singh Chawla
%T Russian site peddles paper authorship in reputable journals for up to
   $5000 a pop
%J Science
%V ?
%M APR
%D 2022
%K news, Abalkina, c2022, c202x, c20xx, zz0422, university, scientific,
   research, paper mill, papers, publications, academic misconduct, KPI, KPIs,
   fake, fraud, author, PaperMill, ghostwriting, Russia, Russian, LLC
%X "Since 2019, Anna Abalkina has been monitoring a website that offers an
   illicit way for scientists to burnish their CVs. The site, operated from
   Russia, openly offers to sell authorship slots on soon-to-be-published
   sci.papers, for fees ranging from several hundred dollars to nearly $5000.
   ..."
   -- [doi:10.1126/science.abq4090]['22],
   and report at [arxiv]['22].
   [Also search for: academic misconduct] & [also search for: PaperMill] etc..

%A M. H. Christiansen
%A N. Chater
%T The Language Game: How Improvisation Created Language and Changed the World
%I BasicBooks
%P 304
%M FEB
%D 2022
%K book, c2022, c202x, c20xx, zz0422, learning, evolution, linguistics,
   natural language
%X 1st ed 2022; hb us$17; uk us isbn:1541674987; uk us isbn13:978-1541674981.
   "... shows how people learn to talk not by acquiring fixed meanings & rules,
   but by picking up, reusing, & recombining countless linguistic fragments in
   novel ways. Talking is verbal charades- an improvisational game of spinning
   intricate patterns of words to get the message across. Each improvisation
   builds on the last, creating the richly layered patterns that comprise a
   language. The patterns in l. are not wired into our brains or our genes ..."

%A O. Gunturkun
%T The conscious crow
%J Learning & Behavior
%V 49
%P 3-4
%M FEB
%D 2021
%K jrnl, c2021, c202x, c20xx, zz0422, animal, bird, crow, crows, behaviour,
   brain, neuron, consciousness
%X "Nieder, Wagener, & Rinnert (Science, 369(6511), 1626-1629, 2020) demo. that
   some neurons in a prefrontal-like brain area of carrion crows signal neither
   the physical stimulus nor the intended action but the upcoming choice. This
   pattern of results implies that neural computations for consciousness can be
   generated by nonmammalian brains in similar ways as in primates."
   -- [doi:10.3758/s13420-021-00466-5]['22],
      [www]['22].

%A S. Baron
%A K. Miller
%A J. Tallant
%T Out of Time: A Philosophical Study of Timelessness
%I OUP
%P 288
%M APR
%D 2022
%K book, text, OUP, c2022, c202x, c20xx, zz0422, time, timelessness, physics,
   quantum, gravity, space, cause, causal, causation
%X 1st ed 2022; us%68; uk us isbn:0192864882; uk us hb isbn13:978-0192864888.
   "The idea that time does not exist is, for many, unthinkable: time must
   exist. Almost every experience we have tells us so. There has been plenty of
   debate around what time is like, but not whether it exists. The goal of this
   book is to make the absence of time thinkable. Time might not exist.
   Beginning with an empirically flavoured examination of the 'folk' concept of
   time, the book explores the implications this has for our understanding of
   agency, and the extent to which our best physics and best metaphysics are
   compatible with a timeless conception of reality."
   (Also see [abc]['17/4/2022].)
   [Also search for: physics time].

%T The state of Fortran
%M MAR
%D 2022
%K Fortran, TR, c2022, c202x, c20xx, zz0422, computer programming language,
   scientific computing
%X "A community of developers has formed to modernize the Fortran ecosystem. ...
   we describe the high-level features of Fortran that continue to make it a
   good choice for scientists & engineers in the 21st century. Ongoing efforts
   inc. the development of a Fortran std library & package manager, the
   fostering of a friendly & welcoming online community, improved compiler
   support, & language feature development. The lessons learned are common
   across contemporary prog.langs. & help reduce the learning curve & increase
   adoption of Fortran."
   -- 2203.15110@[arXiv]['22].

%A H. E. Robbins
%T An empirical Bayes approach to statistics
%J Berkeley Symp. on Maths, Stats & Prob.
%V 3.1
%D 1956
%K jrnl, c1959, c195x, c19xx, zz0422, empirical Bayes method, EBM, stats
%X "Let X be a random var. which for simplicity we shall assume to have discrete
   values x & which has a prob.distn depending in a known way on an unknown real
   parameter A,  p(x|l) = Pr(X=x|A=l). A itself being a random var. with apriori
   distn fn G(l) = Pr(A<=l). ..."
   -- [doi:10.1007/978-1-4612-0919-5_26]['22],
      [eucl'd]['22].
   Also see, "... procedures for statistical inference in which the prior
   distribution is estimated from the data. ..."
   -- EBM@[wikip]['22].
   [Also search for: empirical Bayes stats].

%A B. Efron
%T Bayes, oracle Bayes and empirical Bayes
%J Statist. Sci.
%V 34
%N 2
%P 177-201
%M MAY
%D 2019
%K jrnl, c2019, c201x, c20xx, zz0422, stats, oracle, empirical Bayes
%X "... concerns the Bayes & frequentist aspects of empirical B. inference. Some
   of the ideas explored go back to Robbins in the 1950s, while others are
   current. Several examples are discussed, real & artificial, illustrating the
   two faces of empirical Bayes methodology: 'oracle Bayes' shows empirical B.
   in its most frequentist mode, while 'finite B. inference' is a fundamentally
   Bayesian application. In either case, modern theory & computation allow us to
   present a sharp finite-sample picture of what is at stake in an empirical B.
   analysis."
   -- [doi:10.1214/18-STS674]'22].
   [Also search for: empirical Bayes stats].

%A D. Flusfeder
%T Luck: A Personal Account of Fortune, Chance and Risk in
   Thirteen Investigations
%I 4thEstate
%P 304
%D 2022
%K book, c2022, c202x, c20xx, zz0422, probability, gambling, luck, lucky,
   chance, fortune, risk, randomness
%X hb $22; uk us isbn:0008245177; uk us isbn13:978-0008245177.
   "... take[s] [DF] to Siberia, Versailles, the Old Testament desert; play
   roulette in Baden-Baden with Dostoevsky; visit a Cambridge fairground with
   Wittgenstein; meet the sixteenth-C poet Thomas Bastard, who challenged
   Fortune, and lost ..."
   [Also search for: probability book].